A Korean research team has successfully proposed a new cause for the onset of dementia, a condition that has been difficult to treat and prevent due to its previously unknown origins. This discovery ...

The goal of my research program is to define the molecular mechanisms that regulate how glial cells take on harmful or beneficial cell states in health and disease. I am particularly interested in how ...

When the brain is injured in some way, a wide range of biochemical changes are triggered that can affect crucial brain cells known as astrocytes. They are a type of glial cell, and brain injuries ...

A new platform for screening astrocyte reactivity helps researchers uncover potential therapeutic interventions to treat neurodegenerative conditions. Led by postdoctoral researcher Benjamin Clayton, ...

In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS, excessive H2O2 from reactive astrocytes triggers a vicious cycle of oxidative stress, protein aggregation, and neuronal loss.

Much of the brain is made up of a constellation of star-shaped cells called astrocytes, which play vital roles in immunity, neuron maintenance and many other functions. In Alzheimer’s disease, some ...

How do astrocytes react to Alzheimer’s disease pathology? It’s complicated, according to the largest single-nuclei RNA-Seq study of these cells published thus far. Scientists led by Sudeshna Das at ...

UT Southwestern Medical Center scientists have identified a protein that appears to act as a master control switch for reactive gliosis, a prominent feature of many neurodegenerative diseases that is ...

An experimental drug developed at Northwestern University has demonstrated further promise as an early intervention for Alzheimer's disease. Subscribe to our newsletter for the latest sci-tech news ...

The selective MAOB inhibitor KDS2010 significantly improved functional recovery in a spinal cord injury animal model. Treated animals showed marked restoration of behavioral scores and locomotor ...